abstract：:Considerable evidence indicates that the state of ocular connective tissues and their response in glaucomatous disease affect the degree of glaucoma damage. Both experimental and clinical data suggest that improved diagnostic and prognostic information can be derived from the assessment of the mechanical responsivenes...

journal_title：Cell and tissue research

authors： Quigley HA,Cone FE

更新日期：2013-08-01 00:00:00

abstract：:Dental pulp stem cells (DPSCs) are an attractive alternative mesenchymal stem cell (MSC) source because of their isolation simplicity compared with the more invasive methods associated with harvesting other MSC sources. However, the isolation method to be favored for obtaining DPSC cultures remains under discussion. T...

journal_title：Cell and tissue research

authors： Hilkens P,Gervois P,Fanton Y,Vanormelingen J,Martens W,Struys T,Politis C,Lambrichts I,Bronckaers A

更新日期：2013-07-01 00:00:00

abstract：:SEPTIN9 (SEPT9) is a filament-forming protein involved in numerous cellular processes. We have used a conditional knock out allele of Sept9 to specifically delete Sept9 in T-cells. As shown by fluorescence-activated cell sorting, loss of Sept9 at an early thymocyte stage in the thymus results in increased numbers of d...

journal_title：Cell and tissue research

authors： Lassen LB,Füchtbauer A,Schmitz A,Sørensen AB,Pedersen FS,Füchtbauer EM

更新日期：2013-06-01 00:00:00

abstract：:This study aims to illustrate potential transport mechanisms behind the divergent approaches to nitrogen excretion seen in the ureotelic toadfish (Opsanus beta) and the ammoniotelic plainfin midshipman (Porichthys notatus). Specifically, we wish to confirm the expression of a urea transporter (UT), which is found in t...

journal_title：Cell and tissue research

authors： Bucking C,Edwards SL,Tickle P,Smith CP,McDonald MD,Walsh PJ

更新日期：2013-06-01 00:00:00

abstract：:iASPP (inhibitory member of the ASPP family), the conserved key inhibitor of p53, is overexpressed and plays an important oncogenetic role in many human cancers. However, its function in cervical cancer remains unknown. The objective of this study was to investigate the expression and clinical relevance of iASPP in ce...

journal_title：Cell and tissue research

authors： Cao L,Huang Q,He J,Lu J,Xiong Y

更新日期：2013-05-01 00:00:00

abstract：:In plants, intercellular structures named plasmodesmata (PD) form a continuous cytoplasmic network between neighboring cells. PD pores provide channels for intercellular symplasmic (cell-to-cell) transport throughout most tissues of the plant body. Cell-defining proteins, such as transcription factors, and regulatory ...

journal_title：Cell and tissue research

authors： Kragler F

更新日期：2013-04-01 00:00:00

abstract：:Conventional two-dimensional cell monolayers do not provide the geometrical, biochemical and mechanical cues found in real tissues. Cells in real tissues interact through chemical and mechanical stimuli with adjacent cells and via the extracellular matrix. Such a highly interconnected communication network extends alo...

journal_title：Cell and tissue research

authors： Pampaloni F,Ansari N,Stelzer EH

更新日期：2013-04-01 00:00:00

abstract：:The effects, on the maternal mammary gland, of diets containing similar lipid percentages but differing in composition of polyunsaturated fatty acids (PUFA) have been assessed in rats during pregnancy and lactation. For this purpose, tuna fish oil (an n-3-PUFA-enriched oil) and corn oil (an n-6-PUFA-enriched oil) were...

journal_title：Cell and tissue research

authors： Delpal S,Pauloin A,Hue-Beauvais C,Berthelot V,Schmidely P,Ollivier-Bousquet M

更新日期：2013-03-01 00:00:00

abstract：:Serine proteases, cysteine proteases, aspartic proteases and matrix metalloproteinases play an essential role in extracellular matrix remodeling and turnover through their proteolytic action on collagens, proteoglycans, fibronectin, elastin and laminin. Proteases can also act on chemokines, receptors and anti-microbia...

journal_title：Cell and tissue research

authors： Biancheri P,Di Sabatino A,Corazza GR,MacDonald TT

更新日期：2013-02-01 00:00:00

abstract：:In the atherosclerotic plaque, smooth muscle cells (SMC) acquire an inflammatory phenotype. Resistin and fractalkine (CX3CL1) are found in human atheroma and not in normal arteries. CX3CL1 and CX3CR1 are predominately associated with SMC. We have questioned whether resistin has a role in the expression of CX3CL1 and C...

journal_title：Cell and tissue research

authors： Gan AM,Butoi ED,Manea A,Simion V,Stan D,Parvulescu MM,Calin M,Manduteanu I,Simionescu M

更新日期：2013-01-01 00:00:00

abstract：:Induction of HIF-1α by oxygen limitation promotes increased phosphorylation and catalytic depression of mitochondrial pyruvate dehydrogenase (PDH) and an enhanced glycolytic poise in cells. Cobalt chloride and desferrioxamine are widely used as mimics for hypoxia because they increase the levels of HIF-1α. We evaluate...

journal_title：Cell and tissue research

authors： Borcar A,Menze MA,Toner M,Hand SC

更新日期：2013-01-01 00:00:00

abstract：:Long-term in vitro culture (16 days) of caprine ovarian cortical tissue was performed to test the effect of FSH and IGF-I on the viability and development of preantral follicles and mRNA expression for FSH and IGF-I receptors. Fragments were cultured in α-MEM(+) alone or supplemented with different combinations of FSH...

journal_title：Cell and tissue research

authors： Magalhães-Padilha DM,Fonseca GR,Haag KT,Wischral A,Gastal MO,Jones KL,Geisler-Lee J,Figueiredo JR,Gastal EL

更新日期：2012-12-01 00:00:00

abstract：:The dental follicle is an ectomesenchymal tissue that surrounds developing tooth germ and that contains osteoblastic-lineage-committed stem/progenitor cells. We examined the osteogenic potential of human dental follicle cells (hDFC) by microarray analysis. We first compared the characteristics of hDFC with those of hu...

journal_title：Cell and tissue research

authors： Aonuma H,Ogura N,Takahashi K,Fujimoto Y,Iwai S,Hashimoto H,Ito K,Kamino Y,Kondoh T

更新日期：2012-11-01 00:00:00

abstract：:The distribution of cochlin and its associated basement membrane proteins (collagen IV, collagen II, laminin-β2, and nidogen-1) were evaluated in the vestibular endorgans of subjects with Meniere's disease and compared with normal specimens. Cochlin mRNA expression in vestibular endorgans from Meniere's disease specim...

journal_title：Cell and tissue research

authors： Calzada AP,Lopez IA,Beltran Parrazal L,Ishiyama A,Ishiyama G

更新日期：2012-11-01 00:00:00

abstract：:Progenitor stem cells have been identified, isolated and characterized in numerous tissues and organs. However, their therapeutic potential and the use of these stem cells remain elusive except for a few progenitor cells from bone marrow, umbilical cord blood, eyes and dental pulp. The use of bone marrow-derived hemat...

journal_title：Cell and tissue research

authors： Vishnubalaji R,Al-Nbaheen M,Kadalmani B,Aldahmash A,Ramesh T

更新日期：2012-10-01 00:00:00

abstract：:Urocortin (UCN) is a 40-amino-acid peptide and a member of the corticotropin-releasing hormone (CRH) family, which includes CRH, urotensin I, sauvagine, UCN2 and UCN3. The biological actions of CRH family peptides are mediated via two types of G-protein-coupled receptors, namely CRH type 1 receptor (CRHR1) and CRH typ...

journal_title：Cell and tissue research

authors： Squillacioti C,De Luca A,Alì S,Paino S,Liguori G,Mirabella N

更新日期：2012-10-01 00:00:00

abstract：:Although several studies have shown a dysregulation of microRNA (miRNA) expression profiles in cutaneous melanoma, there has been little research on the miRNA machinery itself. In this study, we investigated the mRNA expression profiles of different miRNA machinery components in primary cutaneous malignant melanoma (P...

journal_title：Cell and tissue research

authors： Sand M,Skrygan M,Georgas D,Sand D,Gambichler T,Altmeyer P,Bechara FG

更新日期：2012-10-01 00:00:00

abstract：:Type 1 diabetes is an autoimmune disorder characterized by a lack of insulin production by the beta cells of the pancreas. This lack of insulin causes a variety of systemic effects on whole-body metabolism. Poorly managed type 1 diabetes can lead to cardiovascular disease, diabetic neuropathy, and diabetic retinopathy...

journal_title：Cell and tissue research

authors： Schoeller EL,Schon S,Moley KH

更新日期：2012-09-01 00:00:00

abstract：:The interstitial cells of Cajal (ICCs) are important mediators of gastrointestinal (GI) motility because of their role as pacemakers in the GI tract. In addition to their function, ICCs are also structurally distinct cells most easily identified by their ultra-structural features and expression of the tyrosine kinase ...

journal_title：Cell and tissue research

authors： Ball ER,Matsuda MM,Dye L,Hoffmann V,Zerfas PM,Szarek E,Rich A,Chitnis AB,Stratakis CA

更新日期：2012-08-01 00:00:00

abstract：:During developmental critical periods, external stimuli are crucial for information processing, acquisition of new functions or functional recovery after CNS damage. These phenomena depend on the capability of neurons to modify their functional properties and/or their connections, generally defined as "plasticity". Al...

journal_title：Cell and tissue research

authors： Foscarin S,Rossi F,Carulli D

更新日期：2012-07-01 00:00:00

abstract：:Myogenesis is a complex process in which committed myogenic cells differentiate and fuse into myotubes that mature into the muscle fibres of adult organisms. This process is initiated by a cascade of myogenic regulatory factors expressed upon entry of the cells into the myogenic differentiation programme. However, ext...

journal_title：Cell and tissue research

authors： Vaz R,Martins GG,Thorsteinsdóttir S,Rodrigues G

更新日期：2012-06-01 00:00:00

abstract：:Orexins (OxA and OxB) and their receptors (Ox1R and Ox2R), originally detected in the hypothalamus, have also been localized in multiple cerebral areas and peripheral organs. Thus, in addition to their central function in the regulation of food intake, arterial blood pressure, heart rate, sleep/wake cycle, sexual beha...

journal_title：Cell and tissue research

authors： Assisi L,Tafuri S,Liguori G,Paino S,Pavone LM,Staiano N,Vittoria A

更新日期：2012-06-01 00:00:00

abstract：:Mechanisms underlying the unique survival property of human spiral neurons are yet to be explored. P75 (p75(NTR)) is a low affinity receptor for neurotrophins and is known to interact with Trk receptors to modulate ligand binding and signaling. Up-regulation of this receptor was found to be associated with apoptosis a...

journal_title：Cell and tissue research

authors： Liu W,Glueckert R,Kinnefors A,Schrott-Fischer A,Bitsche M,Rask-Andersen H

更新日期：2012-06-01 00:00:00

abstract：:Sudden death in athletes occurs because of the existence of hidden cardiovascular disorders which, during effort, may jeopardize the electrical stability of the heart, triggering ventricular tachycardia and/or fibrillation. Apart from rare conditions of ion channel diseases in the setting of a structurally normal hear...

journal_title：Cell and tissue research

authors： Thiene G,Corrado D,Rigato I,Basso C

更新日期：2012-05-01 00:00:00

abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with highly potent neurotrophic and neuroprotective effects. PACAP and its receptors occur in the retina and PACAP has been applied in animal models of metabolic retinal disorders to reduce structural and functional damage. Furthermore, PACAP...

journal_title：Cell and tissue research

authors： Szabadfi K,Atlasz T,Kiss P,Reglodi D,Szabo A,Kovacs K,Szalontai B,Setalo G Jr,Banki E,Csanaky K,Tamas A,Gabriel R

更新日期：2012-04-01 00:00:00

abstract：:The European shore crab Carcinus maenas and the common hermit crab Pagurus bernhardus are members of the sister taxa Brachyura and Anomura (together forming the taxon Meiura) respectively. Both species share similar coastal marine habitats and thus are confronted with similar environmental conditions. This study sets ...

journal_title：Cell and tissue research

authors： Krieger J,Sombke A,Seefluth F,Kenning M,Hansson BS,Harzsch S

更新日期：2012-04-01 00:00:00

abstract：:The therapeutic potency of delivered mesenchymal stem cells (MSCs) in tissue engineering applications may be improved by priming cells toward a differentiated state via coculture with native, differentiated cells prior to implantation; however, there is a lack of understanding in what may be the most efficacious metho...

journal_title：Cell and tissue research

authors： Seto SP,Casas ME,Temenoff JS

更新日期：2012-03-01 00:00:00

abstract：:Based on its proven anabolic effects on bone in osteoporosis patients, recombinant parathyroid hormone (PTH(1-34)) has been evaluated as a potential therapy for skeletal repair. In animals, the effect of PTH(1-34) has been investigated in various skeletal repair models such as fractures, allografting, spinal arthrodes...

journal_title：Cell and tissue research

authors： Takahata M,Awad HA,O'Keefe RJ,Bukata SV,Schwarz EM

更新日期：2012-03-01 00:00:00

abstract：:From its inception, tissue engineering has had three tenets: cells, biomaterial scaffolds and signaling molecules. Among the triad, cells are the center piece, because cells are the building blocks of tissues. For decades, cell therapies have focused on the procurement, manipulation and delivery of healthy cells for t...

journal_title：Cell and tissue research

authors： Nie H,Lee CH,Tan J,Lu C,Mendelson A,Chen M,Embree MC,Kong K,Shah B,Wang S,Cho S,Mao JJ

更新日期：2012-03-01 00:00:00

abstract：:We compared the bone regeneration potentials of autologous cultured osteoblasts and of bone-marrow-derived autologous MSCs in combination with allogeneic cancellous bone granules in a rabbit radial defect model. Radial shaft defects over 15 mm were made in 26 New Zealand white rabbits. The animals underwent insertion ...

journal_title：Cell and tissue research

authors： Kim SJ,Chung YG,Lee YK,Oh IW,Kim YS,Moon YS

更新日期：2012-02-01 00:00:00

abstract：:This is the first detailed report about the collar enamel of the teeth of Polypterus senegalus. We have examined the fine structure of the collar enamel and enamel organ of Polypterus during amelogenesis by light and transmission electron microscopy. An immunohistochemical analysis with an antibody against bovine amel...

journal_title：Cell and tissue research

authors： Sasagawa I,Yokosuka H,Ishiyama M,Mikami M,Shimokawa H,Uchida T

更新日期：2012-02-01 00:00:00

abstract：:Calcitonin receptor-immunoreactivity (CTR-ir) was found in enteric neurons of the mouse gastrointestinal tract from embryonic day 13.5 (E13.5) to post-natal day 28 (P28). CTR-ir occurred in cell bodies in ganglia of the myenteric plexus extending from the esophagus to the colon and in nerve cells of the submucosal gan...

journal_title：Cell and tissue research

authors： Wookey PJ,Turner K,Furness JB

更新日期：2012-02-01 00:00:00

abstract：:It is clear that the well-described phenomenon of epithelial-mesenchymal transition (EMT) plays a pivotal role in embryonic development, wound healing, tissue regeneration, organ fibrosis and cancer progression. EMTs have been classified into three subtypes based on the functional consequences and biomarker context in...

journal_title：Cell and tissue research

authors： Carew RM,Wang B,Kantharidis P

更新日期：2012-01-01 00:00:00

abstract：:Transforming growth factor-β (TGFβ) is the prototype for a large family of pleiotropic factors that signal via heterotetrameric complexes of type I and type II serine/threonine kinase receptors. Important intracellular mediators of TGFβ signaling are members of the Smad family. Smad2 and 3 are activated by C-terminal ...

journal_title：Cell and tissue research

authors： Heldin CH,Moustakas A

更新日期：2012-01-01 00:00:00

abstract：:Protein kinase C (PKC) is overexpressed in cancer, including pancreatic cancer, compared with normal tissue. Moreover, PKCα is considered one of the biomarkers for the diagnosis of cancers. In several human cancers, the claudin tight junction molecules are abnormally regulated and are thus promising molecular targets ...

journal_title：Cell and tissue research

authors： Kyuno D,Kojima T,Ito T,Yamaguchi H,Tsujiwaki M,Takasawa A,Murata M,Tanaka S,Hirata K,Sawada N

更新日期：2011-12-01 00:00:00

abstract：:In the central nervous system, serotonergic and dopaminergic signaling is terminated by the activity of specialized transporter proteins for serotonin (SERT) and dopamine (DAT). These transporter proteins are found both on the cell surface and in intracellular transport vesicles. Trafficking between these subcellular ...

journal_title：Cell and tissue research

authors： Hohmann S,Schweinfurth N,Lau T,Deuschle M,Lederbogen F,Banaschewski T,Schloss P

更新日期：2011-11-01 00:00:00

abstract：:Placenta-derived stem cells (PDSCs) have gained interest as an alternative source of stem cells for regenerative medicine because of their potential for self-renewal and differentiation and their immunomodulatory properties. Although many studies have characterized various PDSCs biologically, the properties of the sel...

journal_title：Cell and tissue research

authors： Kim MJ,Shin KS,Jeon JH,Lee DR,Shim SH,Kim JK,Cha DH,Yoon TK,Kim GJ

更新日期：2011-10-01 00:00:00

abstract：:We have previously demonstrated that tooth size is determined by dental mesenchymal factors. Exogenous bone morphogenetic protein (BMP)4, Noggin, fibroblast growth factor (FGF)3 and FGF10 have no effect on tooth size, despite the expressions of Bmp2, Bmp4, Fgf3, Fgf10 and Lef1 in the dental mesenchyme. Among the wingl...

journal_title：Cell and tissue research

authors： Cai J,Mutoh N,Shin JO,Tani-Ishii N,Ohshima H,Cho SW,Jung HS

更新日期：2011-09-01 00:00:00

abstract：:Aromatase, the enzyme converting androgens into estrogens, is involved in many brain processes such as neural differentiation and plasticity or the prevention of cell death. We have previously observed an increase in aromatase immunoreactivity in sheep neurons exposed in vitro to the oxidant 3-nitro-L: -tyrosine. Howe...

journal_title：Cell and tissue research

authors： Lepore G,Gadau S,Peruffo A,Mura A,Mura E,Floris A,Balzano F,Zedda M,Farina V

更新日期：2011-06-01 00:00:00

abstract：:In fresh-water turtles, the bridge connecting the proximal and caudal stumps of transected spinal cords consists of regenerating axons running through a glial cellular matrix. To understand the process leading to the generation of the scaffold bridging the lesion, we analyzed the mitotic activity triggered by spinal i...

journal_title：Cell and tissue research

authors： Rehermann MI,Santiñaque FF,López-Carro B,Russo RE,Trujillo-Cenóz O

更新日期：2011-06-01 00:00:00